General Hospital (GH) spoilers for the week of November 4-8 reveal that Sam McCall’s (Kelly Monaco) demise will bring some crushing fallout. As the news of Sam’s grim fate spreads, we’ll see plenty of horrified Port Charles residents.

Of course, there’ll be questions about how Sam’s hospital stay went so horribly wrong. It may seem like a case of unexpected complications at first, but an investigation could point to foul play eventually.

GH buzz hints that Cyrus Renault (Jeff Kober) may be to blame for Sam’s demise after putting digitalis in her IV bag. However, Cyrus can be a pretty slippery character, so he may get away with it – at least for now.

Regardless, Danny Morgan (Asher Antonyzyn) and Scout Quartermaine (Cosette Abinante) will spin out after losing their mom, so Jason Morgan (Steve Burton) and Drew Quartermaine (Cameron Mathison) will have to comfort them as best as they can.

Drew and Jason will be dealing with some grief as well since they both cared deeply for Sam. Naturally, Dante Falconeri (Dominic Zamprogna) will be an emotional wreck as he tries to figure out what his future looks like without Sam in it.

The same goes for Alexis Davis (Nancy Lee Grahn), Kristina Corinthos-Davis (Kate Mansi) and Molly Lansing-Davis (Kristen Vaganos) as they struggle to cope with this family crisis.

Molly and Kristina will lash out at each other in the aftermath of this Sam loss, which could leave Alexis even more fed up with them. If there was ever a time for the remaining Davis sisters to band together, it’s now!

Unfortunately, it may take some time before Kristina and Molly realize that. Molly and Kristina will be angry over losing Sam, so they may take that anger out on each other – especially since they’ll feel guilty over their last interaction with her being a tense one.

Rocco Falconeri (Finn Carr), Laura Collins (Genie Francis), Lucky Spencer (Sawandi Wilson), Lucas Jones (Van Hansis) and everyone else connected to Lulu Spencer’s (Alexa Havins) story will struggle with various levels of guilt, too.

Sam’s funeral services arrangements will need to be made sooner or later, so that’ll bring another chance for devastation.

On the bright side, we know Alexa Havins is set to make her debut as a Lulu Spencer recast at some point this fall. It won’t be long until Lulu gets a wakeup call and comes back to her loved ones, but her survival will be bittersweet following Sam’s fatal outcome.

In the meantime, Jenz Sidwell (Carlo Rota) should make his way to Port Charles, so Sonny Corinthos (Maurice Benard) could be in trouble if he doesn’t move those diamonds fast!

Holly Sutton (Emma Samms) will definitely face some backlash over the stolen bling – and that could pull Sasha Gilmore Corbin (Sofia Mattson) into the danger as a result.

General Hospital spoilers say the week of November 4-8 will bring some risky moments and escalating drama, so stick with us for more predictions on the chaos and updates on all the shockers ahead. CDL will have other terrific General Hospital spoilers, predictions, updates and news to read up on, so make us your go-to GH source.